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ICSI Treatment in Hyderabad: Advanced Fertility Care at Mamata Fertility Hospital
ICSI (Intracytoplasmic Sperm Injection) is a lab technique used during IVF. An embryologist injects a single sperm directly into each mature egg. It is mainly used when sperm cannot fertilise eggs on their own, for example:
- very low sperm count or motility
- a zero sperm count where sperm are retrieved surgically
- complete fertilisation failure in a previous IVF cycle
At Mamata Fertility Hospital in Secunderabad, Hyderabad, ICSI is performed in our in-house embryology lab by experienced embryologists.
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Key facts at a glance
| What it is | A lab step within IVF, where one sperm is injected into each egg |
| Main use | Male factor infertility and past fertilisation failure |
| Where | Mamata Fertility Hospital, Secunderabad, Hyderabad |
| Time in the lab | Done a few hours after egg collection |
| Pregnancy test | About 2 weeks after embryo transfer |
| Cost in Hyderabad | [Clinic to confirm, e.g. ₹X to ₹Y per IVF-ICSI cycle] |
| Consultation | Mon to Sat, 8 AM to 6 PM, +91 8790337035 |
What Is ICSI?
In standard IVF, eggs and sperm are placed together in a dish, and sperm fertilise the eggs on their own. In ICSI, the embryologist does that step by hand:
- A single sperm is selected under a high-power microscope.
- It is picked up with a very fine glass needle.
- It is injected directly into the centre of a mature egg.
Everything else is the same as IVF: ovarian stimulation, egg collection, embryo culture and embryo transfer. ICSI only changes how fertilisation happens.
When Is ICSI Recommended?
Quick answer: ICSI is recommended when there is a clear reason sperm may not fertilise eggs on their own. Most often this is a serious sperm problem, surgically retrieved sperm, or fertilisation failure in a past IVF cycle.
Who needs ICSI?
|
Situation |
Is ICSI usually advised? |
Why |
|
Very low sperm count (oligospermia) |
Yes |
Too few sperm to fertilise eggs on their own |
|
Very poor sperm movement (low motility) |
Yes |
Sperm cannot reach or enter the egg |
|
Severely abnormal sperm shape (low morphology) |
Often |
Decided together with count and motility |
|
Zero sperm count (azoospermia) with surgically retrieved sperm |
Yes |
Retrieved sperm need ICSI to fertilise |
|
No or very poor fertilisation in a previous IVF cycle |
Yes |
ICSI helps the sperm get past the fertilisation barrier |
|
Frozen eggs |
Usually |
Freezing hardens the outer shell of the egg |
|
Testing embryos for a single-gene condition (PGT-M) |
Usually |
Avoids extra sperm affecting the genetic test |
|
Normal sperm count and motility |
Usually not needed |
Trials show no added benefit |
|
Unexplained infertility with normal semen |
Not routinely |
Discuss with your doctor |
Does ICSI Improve Pregnancy Rates?
Quick answer: ICSI improves the chance of fertilisation when sperm are the problem. It does not raise live birth rates when sperm are normal.
This is important, because ICSI is sometimes offered to everyone having IVF.
What the research shows
|
Study |
Who was studied |
Finding |
|
Randomised trial, Vietnam, Lancet 2021 |
1,064 couples, male partner with normal sperm count and motility |
ICSI did not give more live births than standard IVF |
|
Randomised trial, 10 centres in China |
2,387 couples with non-severe male factor |
Cumulative live births were 46.7% with ICSI vs 52.6% with standard IVF |
|
Safety reviews |
Children born after ICSI |
Some studies link ICSI with a higher risk of abnormalities, imprinting disorders and birth defects, though most data come from couples with male factor infertility |
What this means for you: if your semen test is normal, ask your doctor whether standard IVF is enough. If there is a real sperm problem, ICSI is the right tool.
ICSI vs IVF: Which Do You Need?
ICSI vs standard IVF
|
Feature |
Standard IVF |
IVF with ICSI |
|
How fertilisation happens |
Sperm and eggs are placed together; sperm enter on their own |
Embryologist injects one sperm into each egg |
|
Best for |
Blocked tubes, endometriosis, ovulation problems, unexplained infertility with normal sperm |
Severe male factor, surgically retrieved sperm, past fertilisation failure, frozen eggs |
|
Sperm needed |
Many healthy moving sperm |
One viable sperm per egg |
|
Lab skill required |
High |
Very high (micromanipulation) |
|
Extra cost |
No |
Yes, an added lab charge |
|
Live birth benefit when sperm are normal |
Standard approach |
No proven benefit |
Not sure which applies to you? Our Male Infertility Treatment guide explains how sperm problems are assessed.
Male Factor Infertility: The Path to ICSI
Before ICSI is planned, the male partner should have a proper evaluation. This finds the cause, and sometimes reveals a treatable problem.
Tests before ICSI
|
Test |
What it checks |
Link |
|
Semen analysis (repeated if abnormal) |
Count, motility, shape |
|
|
Trial sperm wash |
How many good sperm can be prepared |
|
|
Sperm DNA fragmentation test (selected cases) |
Damage to sperm DNA |
|
|
Hormone tests |
FSH, LH, testosterone |
|
|
Genetic tests (very low or zero count) |
Karyotype, Y-chromosome microdeletion, CFTR |
Why genetic testing matters: some genetic causes of male infertility, such as Y-chromosome microdeletions, can be passed to a son born through ICSI. If such a result is found, you will be offered genetic counselling before treatment.
ICSI With Surgically Retrieved Sperm (TESA, PESA, TESE, Micro-TESE)
Quick answer: Yes, ICSI works with surgically retrieved sperm. In fact, it is the only way to use them, because these sperm cannot fertilise an egg on their own.
Where the sperm come from
|
Your situation |
Likely sperm retrieval procedure |
Then |
|
Blockage (obstructive azoospermia) |
ICSI |
|
|
Low sperm production (non-obstructive azoospermia) |
TESE or Micro-TESE |
ICSI |
|
Ejaculation problems |
TESA, or other methods |
ICSI |
|
Sperm frozen before cancer treatment |
Thawed frozen sperm |
ICSI |
Sperm can be retrieved on the day of egg collection, or beforehand and frozen. Your doctor will explain which suits you.
Had Fertilisation Failure in a Previous IVF Cycle?
If none or very few of your eggs fertilised in a past IVF cycle, ICSI is usually advised for the next one. Bring your previous embryology report, which shows how many eggs were collected, how many were mature, and how many fertilised. Our team will review it with you.
The ICSI Process, Step by Step
Your ICSI cycle timeline
|
Stage |
Roughly when |
What happens |
|
1. Assessment |
Before the cycle |
Tests for both partners; treatment plan |
|
2. Ovarian stimulation |
About 8 to 12 days |
Daily injections; scans to track egg growth. See Screening Scan for Hyperstimulation. |
|
3. Trigger injection |
About 36 hours before egg collection |
Final egg maturation |
|
4. Egg collection |
Day 0 |
Under sedation, about 20 to 30 minutes |
|
5. Sperm preparation |
Day 0 |
Fresh, frozen or surgically retrieved sperm are prepared |
|
6. ICSI |
Day 0, a few hours after collection |
One sperm injected into each mature egg |
|
7. Fertilisation check |
Day 1 |
Embryologist checks which eggs fertilised normally |
|
8. Embryo culture |
Days 1 to 5 |
Embryos grow in the lab; time-lapse monitoring where offered |
|
9. Embryo transfer or freezing |
Day 3 or 5 |
Usually one embryo transferred; extra good embryos can be frozen |
|
10. Pregnancy test |
About 2 weeks after transfer |
Blood hCG test |
Only mature eggs can be injected. Not every egg collected will be mature, and not every injected egg will fertilise. This is normal.
How to Judge an ICSI Lab: The Numbers That Matter
Quick answer: A good ICSI lab tracks how many injected eggs fertilise normally and how many are damaged, and compares these numbers with international standards.
International embryology experts set quality benchmarks for IVF labs in the Vienna Consensus (2017):
- Normal fertilisation after ICSI: at least 65% is the minimum competency; 80% or above is the best-practice benchmark.
- Eggs damaged during injection: 10% or below is the competency level; 5% or below is the benchmark.
ICSI Success Rates
Quick answer: ICSI success depends mostly on the woman’s age and egg quality, and on the cause of male infertility. Fertilisation is only the first step. Live birth depends on embryo quality and implantation.
What affects your chances
| Factor | Effect |
| Female partner’s age | The biggest single factor; chances fall with age |
| Number of mature eggs | More mature eggs give more chances for embryos |
| Sperm source and quality | Surgically retrieved sperm from low production may give fewer good embryos |
| Sperm DNA damage | May affect embryo quality in some couples |
| Uterine health | Affects implantation |
| Lab quality | Fertilisation and embryo development rates vary between labs |
Risks and Limitations of ICSI
Risks to know about
|
Risk |
What it means |
|
Egg damage |
A small share of eggs may be damaged by the injection |
|
Fertilisation failure |
Rarely, no eggs fertilise even with ICSI |
|
Genetic inheritance |
Some genetic causes of male infertility can be passed to a child |
|
Birth defects and imprinting disorders |
Studies suggest a small increase in risk, partly linked to the underlying sperm problem |
|
Ovarian hyperstimulation (OHSS) |
From the stimulation medicines, not ICSI itself; monitored with scans |
|
Multiple pregnancy |
Lowered by transferring one embryo at a time |
ICSI does not fix poor egg quality or improve sperm DNA. It only helps the sperm enter the egg.
What About PICSI, IMSI and MACS?
These are add-on sperm selection techniques:
Evidence that they improve live birth rates for most couples is limited. Ask your doctor whether there is a specific reason one may help in your case.
ICSI Treatment Cost in Hyderabad: What to Expect at Mamata Fertility?
At Mamata Fertility Hospital in Secunderabad, we pride ourselves on offering advanced fertility treatments with competitive pricing to make parenthood accessible to all.
Estimated Costs for ICSI
- Initial Evaluation & Diagnostics: ₹10,000–₹20,000
- ICSI Procedure (With IVF): ₹1.8–₹2.8 lakhs per cycle
- Additional Costs: Sperm retrieval techniques (e.g., TESA/PESA), genetic testing, or embryo freezing, if required
Risks and Considerations
Like any fertility treatment, ICSI has potential risks, though they are rare and well-managed at our facility.
Potential Risks
- Egg Damage
The ICSI procedure rarely causes damage to the egg during injection. - Fertilization Failure
While rare, fertilization may not occur if the egg or sperm quality is too poor. - Multiple Pregnancies
Transferring more than one embryo increases the possibility of twins or triplets. - Ovarian Hyperstimulation Syndrome (OHSS)
Resulting from ovarian stimulation medications, OHSS is closely monitored to minimize risk.
Our team takes every precaution to address these risks and provide thorough, transparent guidance at every step.
H2: Why Choose Mamata Fertility Hospital for ICSI in Hyderabad?
- Since 1995: founded by Dr. Mamata Deenadayal, one of the earliest fertility centres in Telangana
- NABH-accredited hospital
- In-house embryology lab led by [Senior Embryologist name, qualifications, years of experience]
- Full male infertility pathway in one place: semen tests, genetic tests, sperm retrieval, ICSI and sperm freezing
- ICSI when it is needed: we explain whether ICSI or standard IVF suits you, based on your tests
- Transparent costs: written estimate before you start
- Support: Counselling Services through every stage
Meet our Fertility Specialists and Dr. Aarti Deenadayal Tolani.
FAQs
What is ICSI treatment?
ICSI is a lab step during IVF where an embryologist injects one sperm directly into each mature egg. It helps when sperm cannot fertilise eggs on their own.
When is ICSI recommended?
Mainly for severe male factor infertility, sperm retrieved by surgery, frozen eggs, and couples whose eggs did not fertilise in a previous IVF cycle.
Is ICSI better than IVF?
Only when there is a sperm-related reason. Large trials show ICSI does not improve live birth rates when the man’s sperm count and motility are normal.
Can ICSI be done with sperm from TESA or PESA?
Yes. ICSI is needed to use surgically retrieved sperm, because these sperm cannot fertilise eggs on their own.
What is the success rate of ICSI?
It depends mainly on the woman’s age, egg quality and the cause of male infertility. In good labs, most injected mature eggs fertilise normally, but pregnancy depends on embryo quality and implantation.
Is ICSI safe for the baby?
Most babies born after ICSI are healthy. Some studies show a small increase in certain risks, partly linked to the sperm problem itself. Genetic testing and counselling help where needed.
Where can I get ICSI treatment in Secunderabad?
Mamata Fertility Hospital in Secunderabad offers ICSI with an in-house embryology lab. Call +91 8790337035 to book.
We Can Help You With All The Possible Infertility Treatments.
At Mamata Fertility Hospital in Secunderabad, we specialize in turning challenges into opportunities with cutting-edge techniques like ICSI. Whether you are dealing with male infertility or need precision-assisted fertilization, our experienced team is ready to help you achieve your dream of parenthood.
Contact us today to schedule a consultation and take the first step on your fertility journey with ICSI treatment in Secunderabad!
Dr Aarti Deenadayal Tolani
MBBS, MS ( OBGYN), FICOG
Clinical Director, Scientific In- Charge & Fertility Consultant with 22+ years Of Experience
TSMC Reg. No. 51895
Her Expertise:
RELATED CONDITIONS
- Ejaculatory Dysfunction
- Low Sperm Count
- Low Sperm Motility
